陈凯先

发布者：中药学院发布时间：2024-05-22浏览次数：253

陈凯先，中国科学院院士

基本信息

电子邮箱：kxchen@simm.ac.cn

招生专业

研究方向：中药药效物质研究

院系名称：中药学院

学位类型：学术学位

专业名称：中药学/100800

简介

陈凯先博士 中国科学院院士，中科院上海药物所研究员，上海中医药大学教授、学术委员会主任，中国药学会和中国中西医结合学会名誉会长。曾任中科院上海药物所所长、上海中医药大学校长，上海市科学技术协会主席，国家药典委员会副主任委员，中国药学会副理事长和监事长，中国中西医结合学会会长，中华中医药学会副会长。

长期致力于新药发现、药物设计和中药活性成分发现及作用靶点研究。两次担任973计划项目首席科学家；先后担任国家科技重大专项“重大新药创制”总体专家组成员和技术副总师。迄今发表论文300多篇，获专利授权20余项。编撰出版了《高等药物化学》、《药物化学进展》等学术专著。曾获上海市科技精英、何梁何利科技进步奖和首届全国科技创新争先奖等多项奖励，为推动我国创新药物研发和中医药现代化、国际化做出了贡献。

近期主要论文

  1. Chenming Gu, Jiayuan Liu, FeiQian, Wenchao Yu, Doudou Huang, Jingshan Shen,Chenguo Feng, Kaixian Chen, YimingLi, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang. Identification of dihydrobenzofuranneolignan as novel PDE4 inhibitors and evaluation of anti-atopic dermatitisefficacy in DNCB-induced mice model. Journal of Medicinal Chemistry, 2024, 67:4855-4869

  2. Yanqiao Xie, Chen Shen, Ge Yin, Siyu Zhang, Yilin Chen, Wenxiang Fan, Kaixian Chen, Zhengtao Wang, Linnan Li, Li Yang.Uncovering the secrets of agarwood aroma according to regions and grades using a comprehensive analytical strategy. Chemical Communications, 2024, 60(27):3709-3712

  3. Jiacheng Xiong, Rongrong Cui, Zhaojun Li, Wei Zhang, Runze Zhang, Zunyun Fu, Xiaohong Liu, Zhenghao Li, Kaixian Chen, Mingyue Zheng.Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application.Acta Pharmaceutica Sinica B, 2024, 14(2):623-634

  4. Chen Hong, Yifan Zhang, Lili Yang, Haoyang Xu,Kang Cheng, Zhi Lv, Kaixian Chen, Yiming Li, Huali Wu. Epimedin B exhibits pigmentation by increasing tyrosinase family proteins expression, activity, and stability. Journal of Pharmaceutical Analysis, 2024, 14(1): 69-85.

  5. Fu Xiao, Xiaoyu Ding, Yan Shi, Dingyan Wang, Yitian Wang, Chen Cui, Tingfei Zhu, Kaixian Chen, Ping Xiang, Xiaomin Luo. Application of ensemble learning for predicting GABAA receptor agonists. Computers in Biology and Medicin. 2024, 169:107958.

  6. Huayan Wu, Longlong Wu, Wenchao Yu, Chenming Gu, Yiming Li, Kaixian Chen, Liuqiang Zhang, Fei Qian. Veronica linariifolia subsp. dilatata ameliorates LPS-induced acute lung injury by attenuating endothelial cell barrier dysfunction via EGFR/Akt/ZO-1 pathway. Journal of Ethnopharmacology, 2024,321:117545.

  7. Maolin Wang, Chenming Gu, Yifu Yang, Liang Chen, Kaixian Chen, Jun Du, Huali Wu, Yiming Li. Ursolic acid derivative UAOS-Na treats experimental autoimmune encephalomyelitis by immunoregulation and protecting myelin. Frontiers in Neurology, 2023, 14:1269862

  8. Shiyuan Fang, Chen Zhang, Shi Qiu, Ying Xiao, Kaixian Chen, Zongyou Lv, Wansheng Chen. Corrigendum: SbWRKY75- and SbWRKY41- mediated jasmonic acid signaling regulates baicalin biosynthesis. Frontiers in Plant Science. 2023, 14:1302112.

  9. Zhenyu Lv, Jiao Meng, Sheng Yao, Fu Xiao, Shilong Li, Haoyang Shi, Chen Cui, Kaixian Chen, Xiaomin Luo, Yang Ye, Chang Chen. Naringenin improves muscle endurance via activation of the Sp1-ERRγ transcriptional axis. Cell Reports, 2023, 42(11): 113288.

  10. Rui Li, Lin Chen, Xinheng He, Duanhua Cao, Zehong Zhang, Hualiang Jiang, Kaixian Chen, Xi Cheng. Loops Mediate Agonist-Induced Activation of the Stimulator of Interferon Genes Protein. Journal of Chemical Information And Modeling, 2023, 63(23): 7373-7381.