郑昌武

发布者：中药学院发布时间：2021-11-16浏览次数：1408

郑昌武，研究员，博士生导师，中药学院副院长

基本信息

办公电话：021-51322026

电子邮箱：zhengcw@shutcm.edu.cn

通讯地址：上海市浦东新区蔡伦路1200号中医药创新楼5楼

招生专业

研究方向：中药活性成分的合成、结构修饰与抗肿瘤活性研究

院系名称：中药学院

学位类型：学术学位、专业学位

专业名称：中药学/100800、中药学/105600

教育经历

2001.09-2005.07   西安交通大学                              获工学学士学位

2005.09-2010.07   中国科学院上海有机化学研究所   获理学博士学位

任职经历

2010.08-2010.12    中国科学院上海有机化学研究所    助理研究员

2010.12-2012.12    威斯康辛大学麦迪孙分校              博士后

2012.12-2015.12    美国西北大学                               博士后

2015.12-2020.12    上海医中医药大学                        副研究员

2021.01-至今          上海医中医药大学                        研究员

获奖及荣誉

曾获教育部高等学校自然科学二等奖、上海市东方学者特聘教授荣誉称号、上海市自然科学一等奖。

承担科研项目情况

  1. 国家自然科学基金青年基金项目，岭南山竹子中活性提取化合物的合成，结构修饰及抗EV71 病毒研究（81602990），主持

  2. 教育部霍英东青年教师基金，单花山竹子中活性氧杂蒽酮类成分的合成，结构修饰及生物活性研究（161039），主持

  3. 上海市自然科学基金，多环多异戊烯基间苯三酚类活性成分的全合成、结构改造和抗肿瘤活性研究（23ZR1461000），主持

主要代表性成果

  1. Zhao, Y.; Luo, Y.; Liu, J.; Zheng, C.; Zhao, G., Multiple Hydrogen-Bonding Catalysts Enhance the Asymmetric Cyanation of Ketimines and Aldimines. Chem. Eur. J. 2023, 29(56), e202302061.

  2. Wu, F.; Li, Z.; Fu, C.; Wang, G.; Zheng, C.; Wu, X., Synergistic Ni/Pd Catalysis for Asymmetric Allylic Alkylation of 2-Acyl Imidazoles. Organic Letters 2023, 25 (29), 5448-5453.

  3. Wang, X.; Feng, J.; Wu, R.; Tan, J.; Huang, Q.; Phang, Y.; Zhang, L.; Fu, W.; Xu, H.; Zheng, C., Garcinol and its analogues: Synthesis, cytotoxic activity and mechanistic investigation. Bioorganic Chemistry 2023, 133, 106389.

  4. Tian, G.; Ji, M.; Wu, F.; Wang, G.; Zheng, C.; Wu, X., Copper-Catalyzed Asymmetric Propargylic Substitution of 2,2,2-Trifluoroethyl-isoxazoles with Propargylic Alcohol Derivatives. Organic Letters 2023, 25 (25), 4666-4671.

  5. Yu, L.; Liu, J.; Wang, H.; Xu, L.; Wu, Y.; Zheng, C.; Zhao, G., Asymmetric Dieckmann Condensation towards Spirocyclic Oxindoles Catalyzed by Amino Acid-derived Phosphonium Salts. Advanced Synthesis & Catalysis 2022, 364 (2), 302-306.

  6. Phang, Y. L.; Liu, S.; Zheng, C.; Xu, H., Recent advances in the synthesis of natural products containing the phloroglucinol motif. Natural Product Reports 2022, 39, 1766-1802.

  7. Liu, S.; Phang, Y. L.; Xu, H.; Zheng, C., Chirality transfer strategy in asymmetric total syntheses. Trends in Chemistry 2022, 4 (11), 969-972.

  8. Wu, H.; Liu, S.; Wang, Y.; Yuan, M.; Zhang, H.; Zhou, H.; Xiao, L.; Zheng, C.; Xu, H., An efficient approach for the synthesis of 1,2-dihydroxanthones enabled by one-pot Claisen condensation/cyclization reactions. Organic & Biomolecular Chemistry 2021, 19 (18), 4126-4131.

  9. Liu, J.; Yu, L.; Zheng, C.; Zhao, G., Asymmetric Synthesis of 2,2-Difluorotetrahydrofurans through Palladium-Catalyzed Formal 3+2 Cycloaddition. Angewandte Chemie-International Edition 2021, 60, 23641–23645.

  10. Wang, X.; Phang, Y.; Feng, J.; Liu, S.; Zhang, H.; Fu, W.; Zhou, H.; Xu, G.; Xu, H.; Zheng, C., Stereodivergent Strategy in Structural Determination: Asymmetric Total Synthesis of Garcinol, Cambogin, and Related Analogues. Organic Letters 2021, 23 (11), 4203-4208.

  11. Wang, L.; Wang, X.; Zhang, G.; Fu, W.; Zhang, H.; Zhou, H.; Xu, H.; Zheng, C., Strategies towards endo-type B polycyclic polyprenylated acylphloroglucinols: total synthesis of regio-hyperibone L and (+)-epi-clusianone. Organic Chemistry Frontiers 2021, 8 (11), 2525-2531.

  12. Zhang, G.; Tan, H.; Chen, W.; Shen, H. C.; Lu, Y.; Zheng, C.; Xu, H., Synthesis of NH-Sulfoximines by Using Recyclable Hypervalent Iodine(III) Reagents under Aqueous Micellar Conditions. Chemsuschem 2020, 13 (5), 922-928.

  13. Phang, Y.; Wang, X.; Lu, Y.; Fu, W.; Zheng, C.; Xu, H., Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action. European Journal of Medicinal Chemistry 2020, 205, 112646.

  14. Du, M.; Yu, L.; Du, T.; Li, Z.; Luo, Y.; Meng, X.; Tian, Z.; Zheng, C.;Cao, W.; Zhao, G., N-Protecting group tuning of the enantioselectivity in Strecker reactions of trifluoromethyl ketimines to synthesize quaternary alpha-trifluoromethyl amino nitriles by ion pair catalysis. Chemical Communications 2020, 56 (10), 1581-1584.

  15. Wang, L.; Sun, L.; Wang, X.; Wu, R.; Zhou, H.; Zheng, C.; Xu, H., Me(2)AISEt-Promoted Domino Dieckmann Cyclization Enables the Total Synthesis of Polycyclic Polyprenylated Acylphloroglucinols. Organic Letters 2019, 21 (19), 8075-8079.

  16. Zheng, C.;Wang, X.; Fu, W.; Lu, Y.; Tan, H.; Xu, H., Total Synthesis of Norsampsones A and B, Garcinielliptones N and O, and Hyperscabrin A. Journal of Natural Products 2018, 81 (11), 2582-2589.