 | 劳远至 副研究员 研究领域：主要的研究方向为中药的抗肿瘤药物
成分筛选、体外和体内机制研究及成药性研究等，
专注于对肿瘤细胞自噬、凋亡、转移以及防止肿
瘤复发等信号通路的研究。 邮箱：laurence_ylao@163.com |
个人简介：
教育背景：
理学学士 1996.9 ～ 2001.6 中国科技大学 生命科学学院
工学学士 1998.9 ～ 2000.7 中国科技大学 电子工程与信息科学系
博士 2003.9 ～ 2008.8 香港科技大学 生物学系
工作经历、进修经历
研发工程师 2001.9 ～ 2002.8 新加坡无线通信研究所
研发工程师 2002.9 ～ 2003.8 新加坡生物工程与纳米技术研究所
博士后 2008.9 ～ 2011.10 英国肿瘤研究所（格拉斯哥）
副教授 2012.1 至今 上海中医药大学 中药学院
所获荣誉、奖项
2014上海中医药大学“杏林学者”。
主要科研成果
我们着重从藤黄属植物中寻找新的具有抗肿瘤活性的有效组分或化合物。我们将GFP-LC3稳定表达的细胞株首次运用在藤黄属化合物库的筛选中，并从中得到了新型自噬抑制剂Oblongifolin C,还系统的研究了其抑制自噬的分子机制，该研究发表在自噬领域著名杂志Autophagy (IF=12.042)上。
主要社会兼职：
Ambassador for European Association for Cancer Research (EACR)
科研领域：
主要从事肿瘤细胞死亡的和DNA损伤信号通路研究，科研方向涉及细胞和分子生物学、转化医学、抗肿瘤小分子药物开发等。专注于对肿瘤细胞自噬、凋亡、转移以及防止肿瘤复发等信号通路的研究。现主持上海市教委科研重点项目一项，参与国家自然科学基金面上项目一项。
主要发表论文列表
1.E. Liu, N. Xu, J, O’prey, Y. Lao, S. Joshia, J. Longa, M. O’Prey, D. Croft, F. Beaumatin, A. Baudot, M. Mrschtik, M. Rosenfeldt, Y. Zhang, D.Gillespie and K. Ryan*. Loss of autophagy causes a synthetic lethal deficiency in DNA repair. PNAS，2015 (Accepted).
2.D. Xu1, Y. Lao1, N. Xu, H. Hu, W. Fu, H. Tan, Y. Gu, P. Cao. H. Xu*. Identification and characterization of anticancer compounds targeting apoptosis and autophagy from Chinese native Garcinia Plants. Planta Medica, 2014 (Accepted). (Co-first author).
3.L. Xu1, Y. Lao1, Y. Zhao, J. Qin, W. Fu, Y. Zhang, H. Xu*. Screening active compounds from Garcinia species native to China reveals novel compounds targeting STAT/JAK signaling patheay. BioMed Research International, 2014 (Accepted). (Co-first author).
4.K. Xiao, Y. Wang, Z. Chang, Y. Lao*, DC. Chang*. P32, a novel binding partner of MCL-1, positively regulates mitochondrial Ca(2+) uptake and apoptosis. Biochem Biophys Res Commun, 2014 Aug 22; 451(2):322-8. (Co-corresponding author).
5.Y. Lao, G. Wan, Z. Liu, X. Wang, P, Ruan, D. Xu, W. Xie, W. Xu, Y. Zhang, H. Xu*, N. Xu*. Natural compound oblongifolin C inhibits autophagic flux and enhances antitumor efficacy of nutrient deprivation. Autophagy, 2014 May 1;10(5):736-49.
6.Y. Lao, X. Wang, N. Xu, H. Zhang, H. Xu*. Application of proteomics to determine the mechanism of action of traditional Chinese medicine remedies. Journal of Ethnopharmacology. 2014 Aug 8;155(1):1-8.
7.H. Zhang, DD Zhang, Y. Lao, WW Fu, S. Liang, QH. Yuan, L. Yang, XH. Xu. Cytotoxic and Anti-Inflammatory Prenylated Benzoylphloroglucinols and Xanthones from the Twigs of Garcinia esculenta. Journal of Natural Products. 2014 Jul 25; 77(7)1700-7.
8.QZ. Zhang, Y. Tian, Y. Lao*, Z. Li*. Peptides-Staple Method Development and Its Application in Cancer Therapy. Current Medicinal Chemistry. 2014, Feb 5. (Co-corresponding author).
9.G. Wan, W. Xie, Z. Liu, W. Xu, Y. Lao, N. Huang, K. Cui, M. Liao, J. He, Y. Jiang, B.B. Yang, H. Xu, N. Xu*, Y. Zhang*. Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway. Autophagy. 2014 Jan;10(1):70-9.
10.P. Ruan, C. Yang, J. Su, J. Cao, C. Ou, C. Luo, Y. Tang, Q. Wang, F. Yang, J. Shi, X. Lu, L. Zhu, H. Qin, W. Sun, Y. Lao* and Y. Li*. Histopathological changes in the liver of tree shrew (Tupaia belangeri chinensis) persistently infected with hepatitis B virus. Virology Journal. 2013 Nov 12;10(1):333. (Co-corresponding author).
11.Z. X. Xia, D. D. Zhang, S. Liang, Y. Z. Lao, H. Zhang, H. S. Tan, S. L. Chen, X. H. Wang, H. X. Xu. Bioassay-Guided Isolation of Prenylated Xanthones and Polycyclic Acylphloroglucinols from the Leaves of Garcinia nujiangensis. Journal of Natural Products, 2012 Aug 24;75(8):1459-64.
12.N. Xu, Y. Lao, Y. Zhang, and D. Gillespie Akt: a double-edged sword in cell proliferation and genome stability. Journal of Oncology, 2012, 2012:951724
13.N, Xu，S. Libertini, E. Black, Y. Lao and D. Gillespie. Cdk phosphorylation of Chk1 is required for efficient activation and checkpoint proficiency. Oncogene, 2012, Mar 1;31(9):1086-94.
14.Y. Lao and D. Chang. Mobilization of Ca2+ from endoplasmic reticulum to mitochondria plays a positive role in the early stage of UV- or TNFα-induced apoptosis. Biochem Biophys Res Commun. 2008, Aug 15;373(1):42-7.
15.H. Fu, W. Li, Y. Lao, J. Luo, N. Lee, K. Kan, H. Tsang, K. Tsim, Y. Pang, Z. Li, D. Chang and Y. Han. Bis(7)-tacrine attenuates β amyloid-induced neuronal apoptosis by regulating L-type calcium channels. Journal of Neurochemistry, 98(2006) 1400-1410.
16.H. Xie, Y. H. Yu, F. Xie, Y. Lao and Z. Gao. Breast Cancer Susceptibility Gene mRNAs Quantified by Microarrays with Electrochemical Detection, Clin. Chem.,50 (2004) 1231-1233.
17.H. Xie, Y. H. Yu, F. Xie, Y. Lao and Z. Gao, An Ultrasensitive Nucleic Acid Biosensor For Gene Expression Analysis in Nanograms of Total mRNA, Anal. Chem., 76 (2004) 4023-4029.
