吴家胜

发布者：中药学院发布时间：2021-10-22浏览次数：3303

吴家胜，副教授，硕士生导师

基本信息

办公电话：021-51322199

电子邮箱：wujiasheng@shutcm.edu.cn

通讯地址：上海市浦东新区蔡伦路1200号

招生专业

研究方向：中药防治代谢性疾病作用机制及药效物质研究

院系名称：中药学院

学位类型：学术学位

专业名称：中药学/100800

教育经历

1999.9-2003.07, 安徽中医药大学, 中药学, 学士

2006.9-2009.07, 上海中医药大学, 药理学, 硕士

2011.09-2014.07, 上海中医药大学, 中药学, 博士

任职经历

2004.01-2008.12, 上海中医药大学, 中药学院, 助教

2009.01-2016.12, 上海中医药大学, 中药学院, 讲师

2016.01-2016.06, 中国科学院，上海药物研究所，访问学者

2017.01-至今, 上海中医药大学, 中药学院, 药理教研室，副教授

获项及荣誉

长期从事中药防治代谢性疾病作用机制及药效物质研究、中药防治慢性肝病（非酒精性脂肪肝、胆汁淤积性肝病、肝纤维化）作用机制及药效物质研究;主持并完成国家自然科学基金、上海市教委计划项目、上海中医药大学杏林学者等科研项目8项, 参与完成国家科技重大新药创制项目2项, 获授权发明专利4项, 发表SCI论文35篇, 其中以第一/通讯（含共同通讯）作者在Phytomedicine, Journal of Proteome Research等期刊发表SCI论文23篇，荣获上海市科技进步奖二等奖1项、中华医学会科技奖二等奖1项，为《药理学》等国家“十四五”规划教材编委。

兼任中华中医药学会中药实验药理学分会青年委员, 上海市药学会药理学专委会青年委员, 上海药理学会药物代谢专业委员会委员, 上海药理学会中药药理专业委员会委员。

承担科研项目情况

  1. 国家自然科学基金项目，基于胆汁酸转运体/代谢酶的黄芪汤改善肝内胆汁淤积的分子机制研究（81503343），主持

  2. 上海市教委计划项目，基于肠道菌群协调肝脏调控胆汁酸稳态的黄芪汤抗胆汁淤积性肝损伤作用机制研究（2020LK017），主持

  3. 上海中医药大学，人才项目，杏林学者，主持

  4. 校企合作项目，金芪降糖胶囊药代动力学研究（20230210），主持

  5. 校企合作项目，夏枯草开音合剂药效学评价研究（20221115），主持

  6. 校企合作项目，金黄软膏制剂药效学及安全性评价研究（H21074），主持

主要代表性成果

1. Su Fang, Tianming Wang, Yuanyuan Li, Haoyu Xue, Juan Zou, Jingyi Cai, Rong Shi, Jiasheng Wu*, Yueming Ma*, Gardenia jasminoides Ellis polysaccharide ameliorates cholestatic liver injury by alleviating gut microbiota dysbiosis and inhibiting the TLR4/NF-κB signaling pathway, International Journal of Biological Macromolecules. 2022, 205:23-36 （*为通讯作者）

2. Qian Meng, Hongwen Zhu, Yuanyuan Li, Xiaotian Peng, Tianming Wang, Hui Huang, Hu Zhou, Yuejia Liu, Sujie Ru, Jiasheng Wu*, Yueming Ma*, Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway, Frontiers in pharmacology, 2024,15:1341020

3. Jingyi Cai, Zhenyun Zhu, Yuanyuan Li, Qi Li, Tian Tian, Qian Meng, Tianming Wang, Yueming Ma*, Jiasheng Wu*, Artemisia capillaris Thunb. Polysaccharide alleviates cholestatic liver injury through gut microbiota modulation and Nrf2 signaling pathway activation in mice, Journal of Ethnopharmacology, 2024, 327:118009

4. Jiasheng Wu, Qian Liu, Shanhua Fang, Xing Liu, Min Zheng, Tianming Wang, Hua Zhang, Ping Liu, Hu Zhou*, Yueming Ma*, Quantitative proteomics reveals the protective effects of Huangqi decoction against acute cholestatic liver injury by inhibiting NF-κB/IL-6/STAT3 signaling pathway, Journal of Proteome Research, 2020, 19(2):677-687

5. Yuanyuan Li, Haoyu Xue, Su Fang, Guofeng Wang, Yahang Wang, Tianming Wang, Rong Shi, Jiasheng Wu*, Yueming Ma*, Time-series metabolomics insights into the progressive characteristics of 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver fibrosis in mice, J Pharm Biomed Anal. 2021, 198:113986

6. Jiasheng Wu, Su Fang, Wenkai Li, Yifei Li, Yuanyuan Li, Tianming Wang, Li Yang, Shaoyong Liu, Zhengtao Wang*, Yueming Ma*. Metabolomics research on the hepatoprotective effect of cultured bear bile powder in α-naphthylisothiocyanate-induced cholestatic mice, Journal of Chromatography B, 2020, 1153, 122269: 1-10

7. Guofeng Wang , Yuanyuan Li, Rong Shi, Tianming Wang, Yifei Li, Wenkai Li, Min Zheng, Fengbo Fan, Juan Zou, Bin Zan, Jiasheng Wu*, Yueming Ma* .Yinchenzhufu Decoction protects against alpha-naphthyl isothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses, Journal of Ethnopharmacology, 2020, 254:112672

8. Wenkai Li, Guofeng Wang, Tianming Wang, Yuanyuan Li, Yifei Li, Xinyi Lu, Wang Yahang Wang, Hua Zhang, Ping Liu, Jiasheng Wu*，Ma Yueming Ma*, Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury through inhibiting bile acid stimulated inflammation in DDC-induced mice, Phytomedicine, 2019, 62:152948

9. Ming Zheng, YuanyuanLi, Guofeng Wang, Jinyi Jin, Yahang Wang, Tianming Wang, Li Yang, Shaoyong Liu, Jiasheng Wu*, Zhengtao Wang*,Yueming Ma*, Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats, Biomedicine & Pharmacotherapy, 2019, 112:108701

10. Yuanyuan Li, Xiaotian Peng 1, Guofeng Wang, Bin Zan 1, Yahang Wang, Juan Zou, Tian Tian, Qian Meng, Rong Shi, Tianming Wang, Jiasheng Wu*, Yueming Ma*, Identifying hepatoprotective mechanism and effective components of Yinchenzhufu decoction in chronic cholestatic liver injury using a comprehensive strategy based on metabolomics, molecular biology, pharmacokinetics, and cytology, Journal of Ethnopharmacology, 2024, 319 (Pt 1):117060.