个人简介 入选上海中医药大学“杏林学者”,主持国家自然科学基金、上海市教委等科研课题多项,参与完成国家自然科学基金、国家重大新药创制等项目多项,在Journal of Proteome Research、Phytomedicine等主流杂志发表SCI论文30余篇,荣获上海市科技进步二等奖、中华医学会科技奖二等奖各1项,申请发明专利8项,其中获授权专利4项,参编《药理学》等国家规划教材3部,荣获全国化学药物及异物代谢学术会议、中国药理学会中药药理联合会、上海市药理学会等青年优秀论文奖多项,为Molecular Pharmaceutics,Journal of Chromatography B等多种SCI源期刊审稿专家,国家自然科学基金青年/面上审评专家。 承担课程 《药理学》、《药理与中药药理学实验》、《三理综合实验》等课程 社会兼职 中华中医药学会中药实验药理学分会青年委员 上海市药学会药理学专业委员会青年委员 研究领域 (1) 运用动物及细胞模型以及多组学技术,研究核受体/代谢酶/转运体影响的内源/外源性代谢物在药源性肝损伤、非酒精性脂肪肝、肝纤维化等肝脏疾病发生发展及转归中的作用; (2) 基于化学物质组、非靶向/靶向代谢组学、微生物组学以及药代动力学等技术与方法,探索中医方剂、中药多糖物质治疗肝纤维化、非酒精性脂肪肝、药源性肝损伤、胆汁淤积等肝脏疾病的代谢调控机制,推动以“肠道菌群”靶向的肝脏疾病治疗的创新中药研发。 教学成果 参编十三五规划教材《药理学》、《药理学题库》以及十四五规划教材《药理学》(人民卫生出版社),以第一负责人主持并完成上海中医药大学课程建设项目3项,获得优秀结题项目1项,以项目骨干参与完成上海市重点课程《中药药理学》;以导师指导本科生毕业设计多名,获得优秀毕业论文2次,指导大学生科创多项,获得优秀结题项目1项,指导本科生以第一作者发表核心期刊论文1篇,指导硕博士生多名,获得国家奖学金及留学基金委资助等。
科研成果(近年发表论文,*通讯作者) [1] Yuanyuan Li, Haoyu Xue, Su Fang, Guofeng Wanga, Yahang Wanga, Tianming Wang, Rong Shi, Jiasheng Wu∗, Yueming Ma∗, Time-series metabolomics insights into the progressive characteristics of 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestatic liver fibrosis in mice. Journal of Pharmaceutical and Biomedical Analysis, 2021, 198: 113986 [2] Juan Zou, Wen-Kai Li, Guofeng Wang, Su Fang, Jingyi Cai, Tianming Wang, Hua Zhang, Ping Liu, Jiasheng Wu*, Yueming Ma*. Hepatoprotective effects of Huangqi decoction (Astragali Radix and Glycyrrhizae Radix et Rhizoma) on cholestatic liver injury in mice: involvement of alleviating intestinal microbiota dysbiosis, Journal of Ethnopharmacology, 2021, doi: 10.1016/j.jep.2021.113544 [3]Jiasheng Wu, Qian Liu, Shanhua Fang, Xing Liu, Min Zheng, Tianming Wang, Hua Zhang, Ping Liu, Hu Zhou*, Yueming Ma*, Quantitative proteomics reveals the protective effects of Huangqi decoction against acute cholestatic liver injury by inhibiting NF-κB/IL-6/STAT3 signaling pathway,Journal of Proteome Research, 2020, 19(2):677-687 [4] Jiasheng Wu, Su Fang, Wenkai Li, Yifei Li, Yuanyuan Li, Tianming Wang, Li Yang, Shaoyong Liu, Zhengtao Wang*, Yueming Ma*. Metabolomics research on the hepatoprotective effect of cultured bear bile powder in α-naphthylisothiocyanate-induced cholestatic mice, Journal of Chromatography B, 2020, 1153, 122269: 1-10 [5] Guofeng Wang , Yuanyuan Li, Rong Shi, Tianming Wang, Yifei Li, Wenkai Li, Min Zheng, Fengbo Fan, Juan Zou, Bin Zan, Jiasheng Wu*, Yueming Ma* .Yinchenzhufu Decoction protects against alpha-naphthyl isothiocyanate-induced acute cholestatic liver injury in mice by ameliorating disordered bile acid homeostasis and inhibiting inflammatory responses, Journal of Ethnopharmacology, 2020, 254:112672 [6] Wenkai Li, Guofeng Wang, Tianming Wang, Yuanyuan Li, Yifei Li, Xinyi Lu, Wang Yahang Wang, Hua Zhang, Ping Liu, Jiasheng Wu*,Ma Yueming Ma*, Protective effect of herbal medicine Huangqi decoction against chronic cholestatic liver injury through inhibiting bile acid stimulated inflammation in DDC-induced mice, Phytomedicine, 2019, 62:152948 [7] Ming Zheng, YuanyuanLi, Guofeng Wang, Jinyi Jin, Yahang Wang, Tianming Wang, Li Yang, Shaoyong Liu, Jiasheng Wu*, Zhengtao Wang*,Yueming Ma*, Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats, Biomedicine & Pharmacotherapy, 2019, 112:108701 [8] Jiasheng Wu, Yifei Li, Yuanyuan Li, Yan Dai, Wenkai Li, Min Zheng, Zhengchun Shi, Rong Shi, Tianming Wang, Bingliang Ma, Ping Liu, Yueming Ma*. Huangqi Decoction alleviates Alpha-Naphthylisothiocyanate induced intrahepatic cholestasis by reversing disordered bile acid and glutathione homeostasis in mice. Frontiers in pharmacology, 2017; 8:938 |