创新中药实验室，成立于2009年，主要负责人黄诚研究员，上海中医药大学博士，中国科学院和美国贝勒医学院博士后。多年从事与代谢综合征和抗肿瘤相关药物的研发和分子机制的研究。具有深厚的分子生物学以及中医药学相关的科研背景。目前已建立国内领先的药物筛选平台。拥有PCR仪、实时荧光定量PCR仪、近红外双波长荧光扫描仪、生物安全柜、显微成像系统等国际领先的仪器设备和操作技术。
研究方向：
以核受体为靶点的治疗代谢综合征药物的筛选与机制研究、药食两用植物的降糖降脂作用与机制研究、复方中药治疗高脂血症和糖尿病的研究、抗肿瘤中药化合物的筛选与机制研究等。
在研项目：
国家自然科学基金的项目 SMARCAL1作为抗肿瘤新靶点的确证与机制（81173141）2012.1-2015.12，经费45万(负责人)
所发表文章：
1. Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y. Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice. J Nutr. 144(7): doi: 10.3945/jn.114.193128. (2014).
2. Huang C. Natural modulators of liver X receptors. J Integr Med. 7(2):76-85, (2014).
3. Fan S, Zhang Y, Sun Q, Zheng B, Wu X, Yang B, Li Y, Huang C. Extract of okra lowers blood glucose and serum lipids in high-fat diet induced obese C57BL/6 mice. J Nutr Biochem. 25: (2014).
4. Tan S, Li M, Ding X, Fan S, Guo L, Gu M, Zhang Y, Feng L, Jiang D, Li Y, Xi W, Huang C, Zhou Z. Effects of Fortunella margarita fruit extract on metabolic disorder in high-fat diet-induced obese C57BL/6 mice. PLoS One. 9(4): e93510, (2014).
5. Li J, Zhang L, Huang C, Guo F, Li Y. Five new cyotoxic steroidal glycosides from the fruits of Solanum torvum. Fitoterapia. 93: 209-215, (2014).
6. Lu Y, Xi W, Ding X, Fan S, Zhang Y, Jiang D, Li Y, Huang C, Zhou Z. Citrange fruit extracts alleviate obesity-associated metabolic disorder in high-fat diet induced C57BL/6 mouse. Int J Mol Sci. 14:23736-23750, (2013).
7. Feng L, Liu X, Zhu W, Guo F, Wu Y, Wang R, Chen K, Huang C, Li Y. Inhibition of human neutrophil elastase by pentacyclic triterpenes. PLoS One. 8(12): e82794, (2013).
8. Gu M, Zhang Y, Fan S, Ding X, Ji G*, Huang C. Extracts of Rhizoma Polygonati Odorati prevent high-fat diet-induced metabolic disorders in C57BL/6 mice. PLoS One. 8(11):e81724, (2013).
9. Ding X, Guo L, Zhang Y, Fan S, Gu M, Lu Y, Jiang D , Li Y, Huang C, Zhou Z. Extracts of pomelo peels prevent high-fat diet-induced metabolic disorders in C57BL/6 mice through activating the PPARα and GLUT4 pathway. PLoS One. 8(10):e77915, (2013).
10. Fan S, Guo L, Zhang Y, Sun Q, Yang B, Huang C. Okra polysaccharide improves metabolic disorders in high-fat diet-induced obese C57BL/6 mice. Mol Nutr Food Res. 57:2075-2078, (2013).
11. Jing L, Zhang Y, Fan S, Gu M, Guan Y, Lu X, Huang C, Zhou Z. Preventive and ameliorating effects of citrus d-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity. Eur J Pharmacol. 715:46-55, (2013).
12. Guo F, Feng L, Huang C, Ding H, Zhang X, Wang Z, Li Y. Prenylflavone derivatives from Broussonetia papyrifera, inhibit the growth of breast cancer cells in vitro and in vivo. Phyto Lett. 6:331-336, (2013).
13. Hu N, Yuan L, Li H-J, Huang C, Mao Q-M, Zhang Y-Y, Lin M, Sun Y-Q, Zhong X-Y, Tang P, Lu X. Anti-diabetic activities of Jiaotaiwan in db/db mice by augmentation of AMPK protein activity and up-regulation of GLUT4 expression. Evid-Based Compl Alt Med. 180721, (2013).
14. 顾明, 黄诚. 减肥药研发: 窘境背后的希望. 中国新药杂志. 22(5): 535-541, (2013).
15. Feng Q, Gou XJ, Meng SX, Huang C, Zhang YQ, Tang YJ, Wang WJ, Xu L, Peng JH, Hu YY. Qushi Huayu Decoction Inhibits Hepatic Lipid Accumulation by Activating AMP-Activated Protein Kinase In Vivo and In Vitro. Evid-Based Compl Alt Med. 184358, (2013).
16. Gu M, Fan S, Liu G, Guo L, Ding X, Lu Y, Zhang Y, Ji G, Huang C. Extract of wax gourd peel prevents high-fat diet-induced hyperlipidemia in C57BL/6 mice via the inhibition of the PPARγ pathway. Evid-Based Compl Alt Med. 342561, (2013).
17. Fan S, Zhang Y , Hu N, Sun Q, Ding X, Li G, Zheng B, Gu M, Huang F, Sun Y-Q, Zhou Z, Lu X, Huang C, Ji G. Extract of kuding tea prevents high-fat diet-induced metabolic disorders in C57BL/6 mice via liver X receptor (LXR) β antagonism. PLoS One. 7(12): e51007, (2012).
18. Ding X, Fan S, Lu Y, Zhang Y, Gu M, Zhang L , Liu G, Guo L, Li Y, Lu X, Zhou Z, Huang C. Citrus ichangensis peel extract exhibits anti-obesity effects by the inhibition of PPARγ and LXR signaling in high-fat diet-induced C57BL/6 mouse. Evid-Based Compl Alt Med. 678592, (2012).
19. Zhang L, Fan S, Liu H, Huang C. Targeting SMARCAL1 as a novel strategy for cancer therapy. Biochem Biophys Res Commun. 427:232-235, (2012).
20. Zhang Y, Fan S, Hu N, Gu M, Chu C, Li Y, Lu X, Huang C. Rhein reduces fat weight in db/db mouse and prevents diet-induced obesity in C57BL/6 mouse through the inhibition of PPARγ signaling. PPAR Res. 374936, (2012).
21. Li Y, Huang W, Huang S, Du J, Huang C. Screening of anti-cancer agent using zebrafish: Comparison with the MTT assay. Biochem Biophys Res Commun. 422:85-90, (2012).
22. Zhang Y, Huang C. Targeting adipocyte apoptosis: A novel strategy for obesity therapy. Biochem Biophys Res Commun. 417:1-4, (2012)
23. Wang P, Guo F, Tan J, Huang C, Wang G, Li Y. A novel C29 sterol from Clerodendrum cyrtophyllum. Chem Nat Comp. 48:594-596, (2012).
24. Feng L, Zhu W, Huang C, Li Y. Direct interaction of ONO-5046 with human neutrophil elastase through 1H NMR and molecular docking. Int J Biol Macromo. 51:196-200, (2012).
25. Gao N, Cheng S, Budhraja A, Gao Z, Chen J, Liu E-H, Huang C, Chen D, Yang Z, Liu Q, Li P, Shi X, Zhang Z. Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway. Br J Pharmacol. 165:1813-1826, (2012).
26. Wang Y, Feng L, Zhang B, Wang X, Huang C, Li Y, Du W. Palladium complexes affect the aggregation of human prion protein PrP106-126. Inorg Chem. 50:4340-4348, (2011).
27. Gao N, Budhraja A, Cheng S, Liu E-H, Huang C, Chen J, Yang Z, Chen D, Zhang Z, Shi X. Interruption of the MEK/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in vitro and in vivo. Apoptosis. 16:511-523, (2011).
28. 李乙根，黄文瑾，黄诚. 斑马鱼在新药发现中的应用。生命科学， 23:273-278, (2011).
29. Chen C, Zhang Y, Huang C. Berberine inhibits PTP1B activity and mimics insulin action. Biochem Biophys Res Commun. 397:543- 547, (2010).
30. Huang C, Gu S, Yu P, Yu F, Feng C, Gao N, Du J. Deficiency of smarcal1 causes cell cycle arrest and developmental abnormalities in zebrafish. Dev Biol. 339:89-100, (2010).
研究人员：
范圣洁 博士研究生
张 玉 博士研究生
冯 丽 博士研究生（联合培养）
张 璐 博士研究生
郭 露 硕士研究生
刘改改 硕士研究生
余丽婧 硕士研究生
臧晴晴 硕士研究生
蔡吴杰 硕士研究生
陈 辉 硕士研究生
联系方法
联系人：黄诚
电话：021-51322182
地址：上海中医药大学中药学院10438室
上海中医药大学2号楼2206室
邮箱：chuang.shutcm@gmail.com
